12th Annual The Cutting Edge in Transplantation:

From End Stage to New Life

Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant

The first successful organ transplant, performed in 1954 by Joseph Murray, involved identical twins, and so no rejection was observed. Otherwise, the number of mismatched gene variants, namely alleles, encoding cell surface molecules called major histocompatibility complex (MHC), classes I and II, correlate with the rapidity and severity of transplant rejection. In humans MHC is also called human leukocyte antigen (HLA).

Ex-transplant patient uses what he learned as a patient and now applies it to others.

It was an ordinary angiogram in the cardiac cath lab at the University of Minnesota Medical Center, Fairview. But
there was nothing ordinary about the technologist scrubbing in as part of the medical team.